Sunday's clash at the Etihad Stadium will be the first Premier League meeting between Pep Guardiola and Erik ten Hag – and the 188th fixture between the two sides.
Last season’s 4-1 rout over the Red Devils ended a three-year wait for a home league victory over our rivals and claiming bragging rights is the aim once again this time around.
They will certainly be looking to write their name in the history of the fixture to add to the swathe of memorable moments from clashes gone by.
When was our first home league success over Manchester United? Who scored our winner in 2012? And how many derby goals has Sergio Aguero scored?
Find out in our quiz below!