City welcome United to the Etihad Stadium on Sunday 11 December, with kick-off scheduled for 12:30 (UK).
It promises to be a must-watch encounter, with both sides vying for the Barclays Women's Super League crown.
Three points against our cross-city rivals could prove significant in our pursuit of domestic success, but we know victory is far from guaranteed.
And with over 40,000 tickets snapped up, everything points towards this weekend's fixture being an historic occasion for the Club.
Gareth Taylor's side have enjoyed plenty of success in the derby in recent years, from Caroline Weir's wonderstrike in our first professional clash with United through to Laura Coombs' unstoppable drive at Leigh Sports Village.
With this in mind, members of the City squad took the time to look back on some of those unforgettable moments ahead of the latest chapter in the saga.
Check out their reactions via the video above...